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ĐÁNH GIÁ ĐỘC TÍNH CẤP, ĐỘC TÍNH BÁN TRƯỜNG DIỄN CỦA VIÊN NANG AN DẠ TRÊN ĐỘNG VẬT THỰC NGHIỆM
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Abstract
* Ngày nhận bài: 30/07/2024
* Ngày phản biện: 19/08/2024
* Ngày phê duyệt đăng bài: 24/08/2024
Objective: The research aims to evaluate the acute toxicity on white mice and the sub-chronic toxicity of An Da capsules. Method: To study the acute toxicity on white mice by oral route using the Litchfield - Wilcoxon method. To evaluate the sub-chronic toxicity on white mice by oral route according to the guidelines of WHO and the Ministry of Health. Results: Acute toxicity and LD50 in white mice were not determined at a dose of 3093 mg/kg, 58.5 times higher than the expected dose for human; After 12 weeks of taking drug, there were not statistically significant different of the white rat’s general health condition, hematological and biochemical indicators, histological indicators of liver and kidneys between the control group and 2 treatment groups (p > 0.05). The increase in the AST and ALT level was statistically significant diffrerent in control group and 2 treatment groups and there were also statistically significant diffrerent between 2 treatment groups (p < 0.01). The ALT level in 2 treatment groups was higher than normal range. Conclusion: An Da capsules didn’t cause acute toxicity and LD50 couldn’t be determined; In sub-chronic toxicity experiment, An Da capsules are safe at both dose of 264 mg/kg/day and 792 mg/kg/day with duration of 12 weeks of research. After 12 weeks of experiment, AST and ALT level was increased in white rats, the ALT level was higher than normal range in white rats.
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Keywords
An Da capsules, acute toxicity, subchronic toxicity.
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