ĐÁNH GIÁ TÁC DỤNG CHỐNG OXY HÓA CỦA CỐM TAN AT7 TRÊN MÔ HÌNH GÂY ĐỘC TNT THỰC NGHIỆM

Abstract

Background: People exposed to Trinitrotoluene (TNT) appear to have many lesions in many organs, the mechanism of damage is thought that TNT generates free radicals in the body. In this study, we evaluated the antioxidant effect of AT7 nuggets on experimental TNT toxicity model. Subjects and methods: This study was carried out on 40 adult rabbits weighing 1.8 - 2 kg. Research under standard conditions, rabbits were divided into 4 research groups, were poisoned with TNT according to the semi-permanent toxicity model of Kong L.Y. (1989) and Toxicological profile for 2, 4, 6-Trinitrotoluene. Then the toxic group was given AT7 instant nuggets, tested after 9 weeks. Results: After 9 weeks of study, it was found that the activities of antioxidant enzymes SOD, GPx, and MDA in the TNT-toxic group given AT7 were higher than those in the group that caused only TNT toxicity with p<0.05. Between the 2 groups of TNT toxicity taking AT7 with different doses, there was no statistically significant difference in the activity of antioxidant enzymes with p > 0.05. Conclusion: After studying the activities of antioxidant enzymes SOD, GPx and MDA concentrations, changes in favor of the body. There was no significant change in antioxidant enzyme activity at doses higher than twice that of the expected human group