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TÁC DỤNG BẢO VỆ GAN CỦA VIÊN NÉN BẢO ĐƯỜNG CAN PC TRÊN MÔ HÌNH THỰC NGHIỆM GÂY VIÊM GAN MẠN BẰNG ETHANOL
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Abstract
The present study evaluated the hepatoprotective effects of Bao đuong can PC tablet on Swiss mice with Ethanol-induced chronic hepatitis. Mice were given Ethanol orally daily, increasing concentrations each week (10%, 20%, 30%, 40%). One hour after taking Ethanol, mice were given distilled water/Bao đuong can PC or silymarin for four weeks. All indexes, including liver weight, biochemical indicators (AST, ALT, GGT, albumin, and total bilirubin levels in the blood), liver malondialdehyde, glutathione concentration, and microscopic analysis, were evaluated. The results showed that Bao đuong can PC at a dose of 1.44 tablets/kg/day exhibited trends to have a hepatoprotective effect on Ethanol-induced chronic hepatitis in mice. At a dose of 4.32 tablets/kg/day, Bao đuong can PC significantly decreased liver weight, mitigated liver enzymes, and further reduced oxidative stress compared to the control group. Additionally, Bao đuong can PC improved the histopathological examination of mice with Ethanol-induced chronic hepatitis. These findings suggested that Bao đuong can PC at a dose of 4.32 tablets/kg/day exerted a hepatoprotective effect against Ethanol-induced liver injury.
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Keywords
Bao đuong can PC, hepatoprotective, Ethanol-induced chronic hepatitis, Swiss mice
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