TÁC DỤNG CHỐNG VIÊM PHỔI CỦA CAO LỎNG MILNALUNG TRÊN THỰC NGHIỆM

Abstract

Milnalung liquid extract is prepared from the modified Cuu vi Khuong hoat thang Remedy. Objectives: To evaluate the anti-inflammatory effect of Milnalung liquid extract on lipopolysaccharide (LPS)-induced pneumonia in Wistar rats. Research method: Induce pneumonia in Wistar rats by intraperitoneal injection of LPS at a dose of 7.5 mg/kg. Evaluate the following indicators: C-reactive protein in the blood of rats; some indicators in bronchial lavage fluid (total cells, protein, NO, LDH); wet/dry ratio of lung parenchyma and lung histopathology. Results: Milnalung liquid extract at doses of 416 mg/kg/day and 832 mg/kg/day reduced C-reactive protein in the blood of rats; reduced total cells, protein, LDH and NO in bronchial lavage fluid; reduced wet/dry ratio of lung parenchyma; improved lung histopathology. The difference was statistically significant compared to the model group with p < 0.01. Conclusion: Milnalung liquid extract at doses of 416 mg/kg/day and 832 mg/kg/day had anti-pneumonia effect induced by Lipopolysaccharide in white rats.