NGHIÊN CỨU TÁC DỤNG GIẢM HO VÀ LONG ĐỜM CỦA CHANH GỪNG ĐƯỜNG PHÈN TRÊN THỰC NGHIỆM

Abstract

The study aimed to evaluate acute toxicity, antitussive and expectorant activities of “Chanh gung duong phen” in the experiment. The antitussive effect of “Chanh gung duong phen” liquid extract was measured using a murine model of ammonia-induced cough. The expectorant effect of “Chanh gung duong phen” liquid extract was evaluated by measuring mice's tracheal phenol red output. “Chanh gung duong phen” liquid extract at both doses of 12 mL/kg and 24 mL/kg significantly inhibited the cough frequency, increased the inhibition of cough, and tended to increase the latent period of cough. In terms of expectorant effect, “Chanh gung duong phen” at the dose of 12 mL/kg tended to enhance mice's tracheal phenol red output while “Chanh gung duong phen” at the dose of 24 mL/kg significantly improved mice's tracheal phenol red output as compared with the control group. In conclusion, “Chanh gung duong phen” was a product derived from herbal medicine, and posed remarkable antitussive, expectorant effects in the experiment.